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초록
The anti-inflammatory activity of fruit body of Phellinus pini was investigated by activity-guided fractionation.From the screening of each fraction for the inhibitory activity of NO production in lipopolysaccaride (LPS) activated RAW264.7 cells, methanol extract and its hexane soluble fraction of Phellinus pini exhibited inhibition of NO production comparedwith LPS control without toxicity. The hexane soluble fraction showed dose-dependent inhibition of NO production. Theactive hexane fraction was repeatedly chromatographed over silica gel, ergosta-7,24(28)-dien-3-ol(1) and ergosterol peroxide50 of them were 18.9±3.9M (1)and 20.4±4.5 uM (2).Keywords . Phelinus pini, ergosta-7,24(28)-dien-3-ol, ergosterol peroxide, nitric oxide, RAW 264.7 cell...... (Phellinus pini(Brot ex Fr.) Ames). ...... (Aphyllophorales), ........ (Hymenochaetaceae)1)
키워드
- 제목
- 낙엽송층버섯의 Nitric Oxide 생성저해 물질
- 제목 (타언어)
- Inhibitors of Nitric Oxide Syntheasis from Phellinus pini in Murine Macrophages
- 저자
- 장현진; 김안근; 표명윤; 양기숙
- 발행일
- 2007-12
- 저널명
- 약 학 회 지
- 권
- 51
- 호
- 6
- 페이지
- 430 ~ 434