ScholarWorks@숙명여자대학교

초록

Objectives: This paper was aimed to investigate the adhesion control standards of pain relieving patch (PRP) drugs andto survey it’s adverse effects on the skin of patients for safe use of PRP drugs. Methods: In this study, the related documentsof PRP drugs of Korea pharmacopoeia (KP), United States pharmacopoeia (USP), Japanese Pharmacopoeia (JP),European pharmacopoeia (EP), and information web sites of the Ministry of Food and Drug Safety (MFDS) were surveyed. Also, the past and current labeling of PRP drugs marketed in the pharmacy was investigated and compared. Results: In KP and JP, the lower limit standard for PRP's adhesion control is established, but the upper limit standardis not designated. In USP and EP, neither the lower nor upper limit standard is established. The main reasons of skinadverse effects are considered as inherent adverse reactions of the applied drugs for PRP. Another reason is involved inpatient's medication mistakes related to PRP's adhesion control, respiratory depression of skin according to physical skinclosure, and microbial growth, etc. Conclusion: For safe use of PRP drugs, we proposed ensured guidelines like additionalinstructions of pharmacist's prescription and detailed labeling systems for usage of PRP drugs applied on skin.

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