상세 보기
- Kim, Sung Wook;
- Hong, In Kyung;
- Kim, Mingee;
- Song, Yun Seon;
- Kim, Kyong-Tai
WEB OF SCIENCE
3SCOPUS
3초록
Protein aggregates of cofilin and actin have been found in neurons under oxygen-glucose deprivation. However, the regulatory mechanism behind the expression of Cfl1 during oxygen-glucose deprivation remains unclear. Here, we found that heterogeneous nuclear ribonucleoproteins (hnRNP) Q and hnRNP A1 regulate the translation of Cfl1 mRNA, and formation of cofilin-actin aggregates. The interaction between hnRNP A1 and Cfl1 mRNA was interrupted by hnRNP Q under normal conditions, while the changes in the expression and localization of hnRNP Q and hnRNP A1 increased such interaction, as did the translation of Cfl1 mRNA under oxygen-glucose deprived conditions. These findings reveal a new translational regulatory mechanism of Cfl1 mRNA in hippocampal neurons under oxygen-glucose deprivation.
키워드
- 제목
- hnRNP Q and hnRNP A1 Regulate the Translation of Cofilin in Response to Transient Oxygen-Glucose Deprivation in Hippocampal Neurons
- 저자
- Kim, Sung Wook; Hong, In Kyung; Kim, Mingee; Song, Yun Seon; Kim, Kyong-Tai
- 발행일
- 2021-12
- 유형
- Article
- 저널명
- Cells
- 권
- 10
- 호
- 12