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초록
A new sesquiterpene lactone was isolated from Siegesbeckia glabrescens as an inhibitor of nitric oxide and prostaglandin E-2 synthesis in the LPS-activated RAW264.7 macrophage cell line. It dose-dependently decreased the protein and mRNA levels of inducible nitric oxide synthase and cyclooxygenase-2. Reporter gene assay revealed that the compound attenuated the LPS-induced DNA transcriptional activity of nuclear factor-kappa B (NF-kappa B). In addition, it inhibited the nuclear translocation of the p65 subunit of NF-kappa B by blocking the inhibitory kappa B-alpha degradation. This compound from Siegesbeckia glabrescens might be beneficial for the treatment of inflammation-related diseases. Copyright (C) 2011 John Wiley & Sons, Ltd.
키워드
nitric oxide; prostaglandin E-2; nuclear factor-kappa B; Siegesbeckia glabrescens; sesquiterpenes; inhibitor; NITRIC-OXIDE SYNTHASE; CELLS; CYCLOOXYGENASE; INFLAMMATION; MACROPHAGES; SUPPRESSION; ACTIVATION
- 제목
- In Vitro Antiinflammatory Activity of a New Sesquiterpene Lactone Isolated from Siegesbeckia glabrescens
- 저자
- Li, Hua; Kim, Jae Yeon; Hyeon, Jinseong; Lee, Hwa Jin; Ryu, Jae-Ha
- DOI
- 10.1002/ptr.3420
- 발행일
- 2011-09
- 유형
- Article
- 권
- 25
- 호
- 9
- 페이지
- 1323 ~ 1327
- 언어
- ENG
- 출판사
- WILEY
- 발행국가
- 미국
- 분량
- 5 페이지
- ISSN
- E 1099-1573
P 0951-418X