Modulation of poly(beta-amino ester) pH-sensitive polymers by molecular weight control

초록

The main objective of this study was to modulate pH-sensitive polymers (poly(beta-amino esters)) by controlling their molecular weight during their synthesis. These pH-sensitive and biodegradable polymers were synthesized by Michael-type step polymerization. 1,4-Butane diol diacrylate was used as the unsaturated carbonyl compound and piperazine as the nucleophilic compound. Various molecular weight polymers were obtained by varying the mol ratio of piperazine/1,4-butane diol diacrylate. The synthesized polymers were characterized by H-1-NMR and their molecular weights were measured by gel permeation chromatography(GPC). The dependence of the molecular weight on the mol ratio as evaluated by the titration method. Also, the pH dependent turbidity of the polymers was determined by UV-Vis spectrophotometry. This pH dependent property of the polymers could be very useful for preparing,drug carriers that are sensitive to pH.

키워드