상세 보기
- Yim, Hwa Young;
- Yang, Young;
- Lim, Jong-Seok;
- Lee, Myeong Seok;
- Zhang, Dong-Er;
- ... Kim, Keun Il
WEB OF SCIENCE
20SCOPUS
22초록
UBP43 (also known as USP18) plays a role in the negative regulation of interferon-alpha/beta signaling, and bone marrow cells in Ubp43-deficient mice exhibited hypersensitivity to interferon-alpha/beta-mediated apoptosis. Here, we show that the mitochondrial apoptotic pathway and reactive oxygen species are major contributors to the elevated interferon-alpha/beta-mediated apoptosis in Ubp43-deficient mouse bone marrow cells and in UBP43-knockdown THP-1 cells. Furthermore, TRAIL and FASL, which were proposed as apoptosis inducers upon interferon-alpha/beta treatment in UBP43-knockdown adherent cancer cells, did not cause apoptosis in these hematopoietic cells. Therefore, although UBP43 depletion can cause hypersensitivity to interferon-alpha/beta-mediated apoptosis in a broad range of cell types, the downstream pathway may vary depending on the cell type. (C) 2012 Elsevier Inc. All rights reserved.
키워드
- 제목
- The mitochondrial pathway and reactive oxygen species are critical contributors to interferon-alpha/beta-mediated apoptosis in Ubp43-deficient hematopoietic cells
- 저자
- Yim, Hwa Young; Yang, Young; Lim, Jong-Seok; Lee, Myeong Seok; Zhang, Dong-Er; Kim, Keun Il
- 발행일
- 2012-06
- 유형
- Article
- 권
- 423
- 호
- 2
- 페이지
- 436 ~ 440