상세 보기
- Kim, Myun Soo;
- Park, Dongmin;
- Lee, Sora;
- Park, Sunyoung;
- Kim, Kyung Eun;
- 외 3명
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1초록
Erythroid differentiation regulator 1 (Erdr1) has previously been reported to control thymocyte selection via TCR signal regulation, but the effect of Erdr1 as a TCR signaling modulator was not studied in peripheral T cells. In this report, it was determined whether Erdr1 affected TCR signaling strength in CD4 T cells. Results revealed that Erdr1 significantly enhanced the anti-TCR antibody-mediated activation and proliferation of T cells while failing to activate T cells in the absence of TCR stimulation. In addition, Erdr1 amplified Ca2+ influx and the phosphorylation of PLC gamma 1 in CD4 T cells with the TCR stimuli. Furthermore, NFAT1 translocation into nuclei in CD4 T cells was also significantly promoted by Erdr1 in the presence of TCR stimulation. Taken together, our results indicate that Erdr1 positively modulates TCR signaling strength via enhancing the PLC gamma 1/Ca2+/NFAT1 signal transduction pathway.
키워드
- 제목
- Erythroid Differentiation Regulator 1 Strengthens TCR Signaling by Enhancing PLC gamma 1 Signal Transduction Pathway
- 저자
- Kim, Myun Soo; Park, Dongmin; Lee, Sora; Park, Sunyoung; Kim, Kyung Eun; Kim, Tae Sung; Park, Hyun Jeong; Cho, Daeho
- 발행일
- 2022-01
- 유형
- Article
- 권
- 23
- 호
- 2