상세 보기
Cellular prion protein regulates invasion and migration of breast cancer cells through MMP-9 activity
- Gil, Minchan;
- Kim, Yun Kye;
- Kim, Kyung-Eun;
- Kim, Wook;
- Park, Chan-Sik;
- 외 1명
Citations
WEB OF SCIENCE
30Citations
SCOPUS
36초록
Function of cellular prion protein (PrPc) in cancer progression has not been elucidated yet. Ectopic expression of PrPc increases the invasion and migration of breast cancer cell line, MCF-7 cells. Over-expressed PrPc increases matrix metalloprotease-9 (MMP-9) expression by enhancing association of NF-kappa B in promoter of MMP-9 gene and ERK signaling in MCF-7 cells. Whereas, silencing of PrPc by siRNA suppresses ERK activation and MMP-9 expression resulting the down-regulation of MD-MB231 cell migration and invasion. Overall, these results suggest that PrPc contribute the breast cancer invasion and migration via MMP-9. (C) 2016 Elsevier Inc. All rights reserved.
키워드
Prion; Matrix metalloprotease-9; Migration; Invasion; Breast cancer; MATRIX METALLOPROTEINASES; COLORECTAL-CANCER; CARCINOMA-CELLS; GASTRIC-CANCER; EXPRESSION; METASTASIS; DEATH; PRNP; PATHWAYS; LINES
- 제목
- Cellular prion protein regulates invasion and migration of breast cancer cells through MMP-9 activity
- 저자
- Gil, Minchan; Kim, Yun Kye; Kim, Kyung-Eun; Kim, Wook; Park, Chan-Sik; Lee, Kyung Jin
- 발행일
- 2016-01
- 유형
- Article
- 권
- 470
- 호
- 1
- 페이지
- 213 ~ 219