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Cellular prion protein regulates invasion and migration of breast cancer cells through MMP-9 activity
- Gil, Minchan;
- Kim, Yun Kye;
- Kim, Kyung-Eun;
- Kim, Wook;
- Park, Chan-Sik;
- 외 1명
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37초록
Function of cellular prion protein (PrPc) in cancer progression has not been elucidated yet. Ectopic expression of PrPc increases the invasion and migration of breast cancer cell line, MCF-7 cells. Over-expressed PrPc increases matrix metalloprotease-9 (MMP-9) expression by enhancing association of NF-kappa B in promoter of MMP-9 gene and ERK signaling in MCF-7 cells. Whereas, silencing of PrPc by siRNA suppresses ERK activation and MMP-9 expression resulting the down-regulation of MD-MB231 cell migration and invasion. Overall, these results suggest that PrPc contribute the breast cancer invasion and migration via MMP-9. (C) 2016 Elsevier Inc. All rights reserved.
키워드
Prion; Matrix metalloprotease-9; Migration; Invasion; Breast cancer; MATRIX METALLOPROTEINASES; COLORECTAL-CANCER; CARCINOMA-CELLS; GASTRIC-CANCER; EXPRESSION; METASTASIS; DEATH; PRNP; PATHWAYS; LINES
- 제목
- Cellular prion protein regulates invasion and migration of breast cancer cells through MMP-9 activity
- 저자
- Gil, Minchan; Kim, Yun Kye; Kim, Kyung-Eun; Kim, Wook; Park, Chan-Sik; Lee, Kyung Jin
- 발행일
- 2016-01
- 유형
- Article
- 권
- 470
- 호
- 1
- 페이지
- 213 ~ 219
- 언어
- ENG
- 출판사
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- 발행국가
- 미국
- 분량
- 7 페이지
- ISSN
- E 1090-2104
P 0006-291X