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Synthesis of π-Extended Heterocycles via Rh(III)-Catalyzed Oxidative Annulation of 5-Aryl Pyrazinones with Alkynes
- Oh, Harin;
- Byun, Hee Won;
- Moon, Kyeongwon;
- Kim, Saegun;
- Ghosh, Prithwish;
- ... Park, Jung Su;
- 외 4명
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10초록
The Rh(III)-catalyzed C-H functionalization and subsequent oxidative annulation between 5-aryl pyrazinones and internal alkynes are reported. This protocol provides facile access to a wide range of pyrazinone-linked naphthalenes via the C(sp2)-H alkenylation and subsequent annulation. This transformation is characterized by mild conditions, simplicity, and excellent functional group compatibility. Notably, it is a first report of the utilization of pyrazinones as directing groups in C-H functionalization. ©
키워드
C-H ACTIVATION; N BOND FORMATION; BIOLOGICAL EVALUATION; CATALYZED ANNULATION; INTERNAL ALKYNES; DIRECTING GROUP; RHODIUM; ACCESS; ROUTE; HOMOLOGATION
- 제목
- Synthesis of π-Extended Heterocycles via Rh(III)-Catalyzed Oxidative Annulation of 5-Aryl Pyrazinones with Alkynes
- 저자
- Oh, Harin; Byun, Hee Won; Moon, Kyeongwon; Kim, Saegun; Ghosh, Prithwish; An, Won; Kwak, Jong Hwan; Park, Jung Su; Mishra, Neeraj Kumar; Kim, In Su
- 발행일
- 2021-12
- 유형
- Article
- 권
- 86
- 호
- 23
- 페이지
- 16349 ~ 16360