In vitro inducible nitric oxide synthesis inhibitors from Alismatis Rhizoma

Kim, NY; Kang, TH; Pae, HO; Choi, BM; Chung, HT; Myung, SW; Song, YS; Sohn, DH; Kim, YC

doi:10.1248/bpb.22.1147

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In vitro inducible nitric oxide synthesis inhibitors from Alismatis Rhizoma

Kim, NY;
Kang, TH;
Pae, HO;
Choi, BM;
Chung, HT;
... Song, YS;
외 3명

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0

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23

초록

Bioassay-guided fractionation of an aqueous extract of Alismatis Rhizoma has furnished two inducible nitric oxide synthase (iNOS) inhibitory compounds, alismol (1) and alisol B monoacetate (2), together with an inactive triterpene, alisol C monoacetate (3). Compounds 1 and 2 inhibited nitric oxide (NO) synthesis in a dose-dependent manner in murine macrophage-like RAW 264.7 cells stimulated with interferon-gamma (IFN-gamma) plus lipopolysaccharide (LPS), The inhibitory effects of 1 and 2 on NO synthesis were partly due to suppression of iNOS mRNA expression as determined by Northern blotting.

키워드

Alismatis Rhizoma; Alismol; Alisol B monoacetate; Inducible nitric oxide synthase (iNOS); Inhibitor; RAW 264.7 cell

제목: In vitro inducible nitric oxide synthesis inhibitors from Alismatis Rhizoma

저자: Kim, NY; Kang, TH; Pae, HO; Choi, BM; Chung, HT; Myung, SW; Song, YS; Sohn, DH; Kim, YC

DOI: 10.1248/bpb.22.1147

발행일: 1999-10

저널명: Biological and Pharmaceutical Bulletin

권: 22

호: 10

페이지: 1147 ~ 1149

언어: ENG

출판사: PHARMACEUTICAL SOC JAPAN

발행국가: 미국

분량: 3 페이지

ISSN: E 1347-5215
P 0918-6158