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초록
The stereoselective synthesis of (-)-centrolobine has been accomplished starting from D-glyceraldehyde acetonide by a combination of chelation-controlled diastereoselective alkylation and ring-closing metathesis. A high degree of 1,3-asymmetric induction has been realized in an ether system. (C) 2014 Elsevier Ltd. All rights reserved.
키워드
ENANTIOSELECTIVE TOTAL-SYNTHESIS; ASYMMETRIC-SYNTHESIS; PRINS CYCLIZATIONS; EFFICIENT APPROACH; MACROLIDE; TETRAHYDROPYRANS; EPIMERIZATION; DIHYDROPYRANS; CONSTRUCTION; SUPPRESSION
- 제목
- Stereoselective synthesis of (-)-centrolobine
- 저자
- Yang, Zunhua; Kim, Hee-Doo
- 발행일
- 2014-02
- 유형
- Article
- 권
- 25
- 호
- 4
- 페이지
- 305 ~ 309