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Negative Regulation of Hypoxic Responses via Induced Reptin Methylation
- Lee, Jason S.;
- Kim, Yunho;
- Kim, Ik Soo;
- Kim, Bogyou;
- Choi, Hee June;
- ... Kim, Keun Il;
- 외 12명
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147초록
Lysine methylation within histones is crucial for transcriptional regulation and thus links chromatin states to biological outcomes. Although recent studies have extended lysine methylation to nonhistone proteins, underlying molecular mechanisms such as the upstream signaling cascade that induces lysine methylation and downstream target genes modulated by this modification have not been elucidated. Here, we show that Reptin, a chromatin-remodeling factor, is methylated at lysine 67 in hypoxic conditions by the methyltransferase G9a. Methylated Reptin binds to the promoters of a subset of hypoxia-responsive genes and negatively regulates transcription of these genes to modulate cellular responses to hypoxia.
키워드
DNA; Humdisease; Proteins; CHROMATIN-REMODELING COMPLEX; HISTONE H3 LYSINE-9; METHYLTRANSFERASE G9A; CANCER-CELLS; INDUCIBLE FACTOR-1; MAMMALIAN-CELLS; GENE-EXPRESSION; BETA; PROTEIN; TRANSCRIPTION
- 제목
- Negative Regulation of Hypoxic Responses via Induced Reptin Methylation
- 저자
- Lee, Jason S.; Kim, Yunho; Kim, Ik Soo; Kim, Bogyou; Choi, Hee June; Lee, Ji Min; Shin, Hi-Jai R.; Kim, Jung Hwa; Kim, Ji-Young; Seo, Sang-Beom; Lee, Ho; Binda, Olivier; Gozani, Or; Semenza, Gregg L.; Kim, Minhyung; Kim, Keun Il; Hwang, Daehee; Baek, Sung Hee
- 발행일
- 2010-07
- 유형
- Article
- 저널명
- Molecular Cell
- 권
- 39
- 호
- 1
- 페이지
- 71 ~ 85