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Photocleavage of DNA by 4 '-bromoacetophenone analogs
- Jeon, R;
- Wender, PA
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5초록
4'-Bromoacetophenone analogs, which are able to generate monophenyl radicals capable of hydrogen atom abstraction, were investigated as possible photoinducibie DNA cleaving agents. The potential of 4'-bromoacetophenone as a possible new DNA cleaver is explored. Pyrrolecarboxatmid conjugated 4'-bromoacetophenones, in particular, DNA cleaving activity and sequence-selectivity on the contiguous AT base pair sites.
키워드
4 '-bromoacetophenone; pyrrolecarboxamide; DNA cleaving agents; phenyl radical; CLEAVAGE; BINDING; PHOTONUCLEASES; ENEDIYNES
- 제목
- Photocleavage of DNA by 4 '-bromoacetophenone analogs
- 저자
- Jeon, R; Wender, PA
- 발행일
- 2001-02
- 유형
- Article
- 권
- 24
- 호
- 1
- 페이지
- 39 ~ 43