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초록
The ethyl acetate soluble fraction of Broussonetia kazinoki at 50 mug/ml showed a significant inhibition (78.2%) of nitric oxide (NO) in lipopolysaccharide activated macrophages. Kazinol B, an isoprenylated flavan, was identified as the active principle. It inhibits the NO synthesis with an IC50 of 21.6 muM (C) 2003 Elsevier Science B.V. All rights reserved.
키워드
Broussonetia kazinoki; nitric oxides; kazinol B; PYRROLIDINE ALKALOIDS; ISOPRENYLATED FLAVANS; CONSTITUENTS; SIEB; COMPONENTS; PLANTS; LEAVES
- 제목
- Inhibition of nitric oxide production on LPS-activated macrophages by kazinol B from Broussonetia kazinoki
- 저자
- Ryu, JH; Ahn, H; 이화진
- 발행일
- 2003-06
- 유형
- Article
- 저널명
- Fitoterapia
- 권
- 74
- 호
- 4
- 페이지
- 350 ~ 354