상세 보기
- Lee, Hwa Jin;
- Lim, Hyo Jin;
- Lee, Da Yeon;
- Jung, Hyeyoun;
- Kim, Mi-Ran;
- ... Kim, Keun Il;
- 외 3명
WEB OF SCIENCE
29SCOPUS
32초록
Carabrol, isolated from Carpesium macrocephalum, showed anti-inflammatory potential in LPS-induced RAW 264.7 murine macrophages. In present study, carabrol demonstrated the inhibitory activity on pro-inflammatory cytokines such as IL-1 beta, IL-6 and TNF-alpha. In addition, mRNA and protein levels of iNOS and COX-2 were reduced by carabrol. Molecular analysis revealed that these suppressive effects were correlated with the inactivation of p38 and JNK via inhibition of NF-kappa B activation. Immunoblotting showed that carabrol suppressed LPS-induced degradation of I-kappa B alpha and decreased nuclear translocation of p65. Taken together, these results suggest that carabrol can be a modulator of pro-inflammatory signal transduction pathway in RAW 264.7 cells. (C) 2009 Elsevier Inc. All rights reserved.
키워드
- 제목
- Carabrol suppresses LPS-induced nitric oxide synthase expression by inactivation of p38 and JNK via inhibition of I-kappa B alpha degradation in RAW 264.7 cells
- 저자
- Lee, Hwa Jin; Lim, Hyo Jin; Lee, Da Yeon; Jung, Hyeyoun; Kim, Mi-Ran; Moon, Dong-Cheul; Kim, Keun Il; Lee, Myeong-Sok; Ryu, Jae-Ha
- 발행일
- 2010-01
- 유형
- Article
- 권
- 391
- 호
- 3
- 페이지
- 1400 ~ 1404