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초록
The isoquinolinone-based tetracyclic compounds were designed and synthesized and their PARP-1 inhibitory activity was evaluated. Most of synthesized compounds showed fairly good activity. Also the most active compound 6 showed its activity on potentiation of anticancer agents, temozolamide and etoposide, by 1.7 times, respectively. (C) 2009 Elsevier Ltd. All rights reserved.
키워드
PARP-1; Isoquinolinone; Cytotoxic potentiation; POLY(ADP-RIBOSE) POLYMERASE; DISCOVERY; ABT-888; AGENTS
- 제목
- Synthesis of isoquinolinone-based tetracycles as poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors
- 저자
- Rhee, Hee-Kyung; Lim, So Yun; Jung, Mi-Ja; Kwon, Youngjoo; Kim, Myung-Hwa; Choo, Hea-Young Park
- 발행일
- 2009-11-01
- 유형
- Article
- 권
- 17
- 호
- 21
- 페이지
- 7537 ~ 7541