상세 보기
- Hong, Subeen;
- Choi, Sae Kyung;
- Wie, Jeong Ha;
- Shin, Jae Eun;
- Jo, Yun Sung;
- ... Yang, Mihi;
- 외 8명
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1초록
Gestational diabetes mellitus (GDM) requires lifestyle changes that may alter exposure to endocrine-disrupting chemicals (EDCs). This study aimed to assess maternal and fetal exposure to EDCs-including bisphenol-A (BPA), monoethyl phthalate (MEP), and perfluorooctanoic acid (PFOA)-during the COVID-19 pandemic and to evaluate their association with fetal birthweight. Maternal urine (second and third trimester) and paired cord blood samples were analyzed from 58 GDM and 118 non-GDM pregnancies using UPLC-MS/MS. Significant correlations were found between maternal urine and cord blood levels of BPA and MEP. Cord blood BPA levels were significantly lower in GDM mothers (0.35 vs. 0.72 mu g/L, p < 0.05), suggesting reduced exposure due to dietary interventions. However, maternal urinary BPA levels in GDM pregnancies were positively associated with fetal birthweight (beta = 2.69, p < 0.05), indicating increased susceptibility to obesogenic effects. PFOA was present in all cord blood but only 41% of maternal urine samples. These findings underscore the dual impact of GDM-related lifestyle changes: reduced EDC transfer to the fetus, yet persistent metabolic vulnerability.
키워드
- 제목
- Effects of Endocrine Disrupting Chemicals on Fetal Weight: Exposure Monitoring Among Mothers with Gestational Diabetes Mellitus and Their Fetuses
- 저자
- Hong, Subeen; Choi, Sae Kyung; Wie, Jeong Ha; Shin, Jae Eun; Jo, Yun Sung; Kim, Yeon Hee; Kang, Byung Soo; Kim, Oyoung; Won, Sangeun; Yoon, Hee Ju; Kim, Hyeon Soo; Park, In Yang; Yang, Mihi; Ko, Hyun Sun
- 발행일
- 2025-04
- 유형
- Article
- 권
- 26
- 호
- 9