상세 보기
- Kim, Kyung-Eun;
- Song, Hyunkeun;
- Hahm, Candace;
- Yoon, Sun Young;
- Park, Sunyoung;
- 외 8명
WEB OF SCIENCE
43SCOPUS
47초록
IL-18 has recently been reported to play a critical role in tumor migration, invasion, and metastasis. Because IL-18 has various biological activities after its secretion as an 18 kDa mature form, the regulation of the IL-18 secretion process is an important step in tumor progression. This study investigated the implication of IL-18 in vascular endothelial growth factor (VEGF)-D-regulated migration, along with the role of the IL-18 secretion process. VEGF-D enhanced cell migration, which was then blocked by inhibiting IL-18. VEGF-D increased 11,48 expression and secretion, suggesting that IL-18 is a critical mediator for VEGF-D-enhanced migration. VEGF-D induced a disintegrin and metalloprotease 33 (ADAM33) expression, which has a metalloproteinase domain. VEGF-D-enhanced IL-18 secretion and cell migration were inhibited by ADAM33 knock-down. Moreover, cell proliferation was considerably reduced in ADAM33 small interfering RNA transfectants. In conclusion, ADAM33 has a key role in gastric cancer pathogenesis by up-regulating IL-18 secretion process, resulting in increased cell migration and proliferation. The Journal of Immunology, 2009, 182: 3548-3555.
키워드
- 제목
- Expression of ADAM33 Is a Novel Regulatory Mechanism in IL-18-Secreted Process in Gastric Cancer
- 저자
- Kim, Kyung-Eun; Song, Hyunkeun; Hahm, Candace; Yoon, Sun Young; Park, Sunyoung; Lee, Ha-reum; Hur, Dae Young; Kim, Taesung; Kim, Cherl-hyun; Bang, Sa Ik; Bang, Jung-Wook; Park, Hyunjeong; Cho, Dae-Ho
- 발행일
- 2009-03
- 유형
- Article
- 권
- 182
- 호
- 6
- 페이지
- 3548 ~ 3555