상세 보기
- Park, Sunyoung;
- Yoon, Sun Young;
- Kim, Kyung-Eun;
- Lee, Ha Reum;
- Hur, Dae Young;
- 외 4명
WEB OF SCIENCE
22SCOPUS
26초록
Interleukin-18 (IL-18) has recently been shown to have a pro-cancer effect in various cancers. Increased serum levels of both IL-18 and transferrin in cancer patients are correlated with its malignancy. However, the relationship between transferrin and IL-18 is not well understood. Here, we show that exogenous transferrin enhanced breast cancer cell proliferation and the proliferation rate was reduced when endogenous transferrin expression was inhibited by transferrin siRNA. The expression of endogenous transferrin was found to be regulated by IL-18. Furthermore, we found that the MAPK pathway is involved in IL-18-induced transferrin production. In conclusion, IL-18 is suggested as an inducer of endogenous transferrin expression in breast cancer cells. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
키워드
- 제목
- Interleukin-18 induces transferrin expression in breast cancer cell line MCF-7
- 저자
- Park, Sunyoung; Yoon, Sun Young; Kim, Kyung-Eun; Lee, Ha Reum; Hur, Dae Young; Song, Hyunkeun; Kim, Daejin; Bang, Sa Ik; Cho, Dae-Ho
- 발행일
- 2009-12
- 유형
- Article
- 저널명
- Cancer Letters
- 권
- 286
- 호
- 2
- 페이지
- 189 ~ 195