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초록
Interleukin (IL)-18, an IL-1 family cytokine, is a pleiotropic immune regulator. IL-18 plays a strong proinflammatory role by inducing interferon (IFN)-. Previous studies have implicated IL-18 in the pathogenesis of various diseases. However, it is not well understood biologic activities of IL-18 in the diverse skin diseases. Here, we have reviewed the expression and function of IL-18 in skin diseases including inflammatory diseases. This article provides an evidence-based understanding of the role of IL-18 in skin diseases and its relationship with disease activities.
키워드
IL-18; psoriasis; atopic dermatitis; urticaria; contact dermatitis; alopecia areata; drug eruption; lupus erythematosus; fibrosis; graft-versus-host disease; skin tumor; skin disease; CORTICOTROPIN-RELEASING HORMONE; INTERLEUKIN-18 PROMOTER POLYMORPHISMS; ALLERGIC CONTACT-DERMATITIS; VERSUS-HOST-DISEASE; ATOPIC-DERMATITIS; ALOPECIA-AREATA; DENDRITIC CELLS; PROTEIN EXPRESSION; INNATE IMMUNITY; SERUM-LEVELS
- 제목
- IL-18 and Cutaneous Inflammatory Diseases
- 저자
- Lee, Ji Hyun; Cho, Dae Ho; Park, Hyun Jeong
- 발행일
- 2015-12
- 유형
- Review
- 권
- 16
- 호
- 12
- 페이지
- 29357 ~ 29369