ScholarWorks@숙명여자대학교

초록

Endocrine disrupting chemicals (EDC) have been emphasized due to their threats in human health. Wasteincinerator emission has been emphasized as a source of EDC including polychlorinateddibenzofurans(PCDD/F) and other carcinogenic polycyclic aromatic hydrocarbons (PAHs). Urinary 1-hydroxypyrene (1--DNA adducts, e.g. 1,N6-ethenodeoxyadenosine (εdA), has been developed as an useful effective or response biomarker forcarcinogenesis. Thus, I investigated association between urinary 1-OHP and εdA levels due to distance from anincinerator which was built more 10 years ago in the middle of a farm in P city. I designated the EDC-high and- ~ 7.5 km from theincinerator, respectively. The study subjects were age and sex-matched males and females (mean age, 61.3±9.6 yrs; total 40 persons, male, 10; female, 10 for the each group). Urinary 1-OHP and εdA were analyzed withHPLC-FD and IP-HPLC-FD, respectively. As results, the distance from the incinerator was not associated withurinary 1-OHP nor εdA levels (p= 0.43 and 0.82, respectively). On the other hand, urinary εdA levels weresignificantly higher in the hyperlipidemia group(N= 10) than normal group (N= 30). In conclusion, urinary 1-OHP nor εdA levels can not be suggested as an incinerator-related exposure nor effective biomarker. However,not only distance from the incinerator bot also systemic approaches including wind and soil contamination arerequired to assume exposure levels of incinerator-related EDC.

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