상세 보기
- Kim, Jae-Hun;
- Sung, Nak-Yun;
- Byun, Eui-Hong;
- Kwon, Sun-Kyu;
- Song, Beom-Seok;
- ... Yoon, Yohan;
- 외 4명
WEB OF SCIENCE
5SCOPUS
6초록
This study evaluated the effects of γ-irradiation on immunomodulating properties and structural changes of β-glucan. β-Glucan solutions (10 ㎎/㎖) were γ-irradiated at 10, 30, and 50 kGy. Splenocyte proliferation and cytokine (interferon-γ and interlukin-2) productions by γ-irradiated β-glucan were evaluated in in vivo and in vitro, and structural changes of β-glucan were also determined after γ-irradiation. γ-Irradiation on β-glucan at 50 kGy enhanced splenocyte proliferation and cytokine productions, (p＜0.05) and cleft glycosidic bonds of β-glucan resulting in lower the molecular weight. These results indicate that the use of γ-irradiation on β-glucan may be useful for improving its immunological activity by lowering the molecular weight of β-glucan.
키워드
- 제목
- Effects of γ-irradiation on immunological activities of β-glucan
- 저자
- Kim, Jae-Hun; Sung, Nak-Yun; Byun, Eui-Hong; Kwon, Sun-Kyu; Song, Beom-Seok; Choi, Jong-Il; Yoon, Yohan; Kim, Jin-Kyu; Byun, Myung-Woo; Lee, Ju-Woon
- 발행일
- 2009-10
- 권
- 18
- 호
- 5
- 페이지
- 1305 ~ 1309