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초록
Anti-inflammatory activity of the extracts of Hibiscus manihot was investigated through the evaluation of its inhibitory effect on the production of inflammatory biomarkers (i-NOS, COX-2) in RAW264.7 murine macrophage cells. Among the sequential solvent fractions (hexane, dichloromethane, ethyl acetate, n-butanol and water), the fractions of dichloromethane (1 μg/ml) and ethyl acetate (5 μg/ml) showed potential inhibitory activities on i-NOS and COX-2 activity in RAW264.7 cells. These results suggest that Hibiscus manihot might have an anti-inflammatory activity through the suppression of inflammatory markers.
키워드
Hibiscus manihot; i-NOS; COX-2; RAW264.7 cells
- 제목
- 황촉규 추출물의 Nitric Oxide 생성 저해활성
- 제목 (타언어)
- Inhibition of Nitric Oxide Production by the Extracts of Hibiscus manihot
- 저자
- 박은영; 양기숙
- 발행일
- 2008-08
- 저널명
- 약 학 회 지
- 권
- 52
- 호
- 4
- 페이지
- 259 ~ 263