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New estrogenic compounds isolated from Broussonetia kazinoki
- Lee, Da Yeon;
- Kim, Do Hee;
- Lee, Hwa Jin;
- Lee, YoungJoo;
- Ryu, Kwang Hee;
- ... Song, Yun Seon;
- 외 2명
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WEB OF SCIENCE
25Citations
SCOPUS
26초록
Two new and two known compounds were identified as estrogenic constituents from Broussonetia kazinoki. Their structures were elucidated as broussonin A (1), tupichinol C (2), kazinol U (3), and (+)-(2R) kazinol I (4). They showed estrogenic activity with ligand-binding activity of estrogen receptor, transcriptional activity of estrogen-responsive element-luciferase reporter genes. They also control the cellular gene expression levels of estrogen-responsive genes. Phytoestrogens from B. kazinoki may have beneficial effects in the treatment of menopausal symptoms. (C) 2010 Elsevier Ltd. All rights reserved.
키워드
Estrogen receptor; Phytoestrogen; Broussonetia kazinoki; BREAST; RECEPTOR; CANCER; BETA; CONSTITUENTS; MECHANISMS; COMPONENT; FLAVANS; ALPHA; CELLS
- 제목
- New estrogenic compounds isolated from Broussonetia kazinoki
- 저자
- Lee, Da Yeon; Kim, Do Hee; Lee, Hwa Jin; Lee, YoungJoo; Ryu, Kwang Hee; Jung, Bo-In; Song, Yun Seon; Ryu, Jae-Ha
- 발행일
- 2010-06-15
- 유형
- Article
- 권
- 20
- 호
- 12
- 페이지
- 3764 ~ 3767