상세 보기
초록
Obesity provokes many serious human diseases, including various cardiovascular diseases and diabetes. Body mass index (BMI) is a highly heritable trait that is broadly used to diagnose obesity. To identify genetic loci associated with obesity in Asians, we conducted a genome-wide association study (GWAS) of a population of Korean adults (n=6,742, age 40∼60 years) and detected six BMI risk loci (TNR, FAM124B, RGS12,NFE2L3, MC4R and FTO) having p＜1×10^(-5). However,in the replication study, only melanocortin 4 receptor gene (MC4R ) (rs9946888, p=4.58×10^(-7)) was replicated with marginal significance (p＜0.05) in the second cohort (n=5,102, age 40∼60 years). This study indicates that each locus associated with BMI has very weak genetic effect.
키워드
- 제목
- Lack of Replication of Genetic Association with Body Mass Index Detected by Genome-wide Association Study
- 제목 (타언어)
- Lack of Replication of Genetic Association with Body Mass Index Detected by Genome-wide Association Study
- 저자
- 이해인; 김재정; 박태성; 김경아; 이종은; 조윤신; 이종영; 한복기; 이종극
- 발행일
- 2011-06
- 권
- 9
- 호
- 2
- 페이지
- 59 ~ 63