ScholarWorks@숙명여자대학교

초록

Three-dimensional (3D) bioprinting technology has opened new possibilities for nanoparticle evaluation. This review discusses the latest research trends using various disease models created through 3D bioprinting for the biological evaluation of nanoparticles. The focus is on tumor models, vascular models, and skin models. In tumor models, evaluations include antitumor effects, gene expression analysis, and cytotoxicity comparisons between 2D and 3D models. Vascular models are used to assess restenosis prevention, ischemic repair, and vascular regeneration. Skin models are employed to investigate nanoparticle toxicity, drug release, and transdermal penetration. These studies highlight the versatility of 3D bioprinting in replicating complex biological environments, enabling more accurate nanoparticle testing. The use of various bioinks and cell types enhances the relevance of in vitro findings. The integration of nanoparticles with 3D-bioprinted models shows significant potential in advancing therapeutic strategies, including cancer treatment, vascular repair, and drug delivery systems. Overall, by providing selected examples to illustrate the concepts, this comprehensive review underscores the importance of 3D bioprinting as an innovative platform for nanoparticle research, bridging the gap between traditional 2D cell cultures and in vivo studies, and contributing to the development of nanomedicines and personalized medical treatments.

키워드