Pimarane cyclooxygenase 2 (COX-2) inhibitor and its structure-activity relationship

Suh, YG; Kim, YH; Park, MH; Choi, YH; Lee, HK; Moon, JY; Min, KH; Shin, DY; Jung, JK; Park, OH; Jeon, RA; Park, HS; Kang, SA

doi:10.1016/S0960-894X(01)00004-X

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Pimarane cyclooxygenase 2 (COX-2) inhibitor and its structure-activity relationship

Suh, YG;
Kim, YH;
Park, MH;
Choi, YH;
Lee, HK;
... Jeon, RA;
외 7명

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29

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SCOPUS

32

초록

The structure-activity relationship and molecular modelings of a novel pimarane COX-2 inhibitor are reported. Particularly, a series of linker extended analogues designed on the basis of these studies exhibited significantly enhanced COX-2 inhibitory activities and selectivities. (C) 2001 Elsevier Science Ltd. All rights reserved.

키워드

ANTIINFLAMMATORY DRUGS; PROSTAGLANDIN; EXPRESSION; SYNTHASE; ACID

제목: Pimarane cyclooxygenase 2 (COX-2) inhibitor and its structure-activity relationship

저자: Suh, YG; Kim, YH; Park, MH; Choi, YH; Lee, HK; Moon, JY; Min, KH; Shin, DY; Jung, JK; Park, OH; Jeon, RA; Park, HS; Kang, SA

DOI: 10.1016/S0960-894X(01)00004-X

발행일: 2001-02-26

유형: Article

저널명: Bioorganic & Medicinal Chemistry Letters

권: 11

호: 4

페이지: 559 ~ 562

언어: ENG

출판사: PERGAMON-ELSEVIER SCIENCE LTD

발행국가: 영국

분량: 4 페이지

ISSN: E 1464-3405
P 0960-894X