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초록
Novel diphenylpiperazine derivatives were synthesized and evaluated for their inhibitory activity against T-type calcium channel by whole-cell patch clamp recordings on HEK293 cells. Among the test compounds, 2 and 3d were effective in decreasing the response to formalin in both the first and second phases and demonstrated antiallodynic effects in a rat model of neuropathic pain. (C) 2010 Elsevier Ltd. All rights reserved.
키워드
T-type calcium channel blocker; Diphenylpiperazine; Formalin test; Neuropathic pain; CA2+ CHANNELS; PAIN; RAT; MIBEFRADIL; ALLODYNIA; BLOCKERS; MODEL
- 제목
- Synthesis and T-type calcium channel blocking activity of novel diphenylpiperazine compounds, and evaluation of in vivo analgesic activity
- 저자
- Kam, Yoo Lim; Rhee, Hee-Kyung; Rhim, Hyewhon; Back, Seung Keun; Na, Heung Sik; Choo, Hea-Young Park
- 발행일
- 2010-08-15
- 유형
- Article
- 권
- 18
- 호
- 16
- 페이지
- 5938 ~ 5944