상세 보기
초록
Hydroxyclemastine was targeted as a versatile analogue of clemastine with H-1 receptor antagonist activity. Stereoselective synthesis of (-)-hydroxyclemastine was performed in which the key step was chelation-controlled diastereoselective 1,2-addition of Grignard reagent to alpha-alkoxyketone.
키워드
hydroxyclemastine; clemastine; H-1 receptor antagonist; chelation; stereoselective; SELECTIVITY
- 제목
- Stereoselective synthesis of (-)-hydroxyclemastine as a versatile intermediate for the H-1 receptor antagonist clemastine
- 저자
- Jung, Jung Wha; Kim, Hee-Doo
- 발행일
- 2007-12
- 유형
- Article
- 권
- 30
- 호
- 12
- 페이지
- 1521 ~ 1525