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초록
The two gericudranin E derivatives, GER-I & II, were synthesized and evaluated their anti-tumour activities for the elucidation of structure-activity relationship. 2,4,6-Trihydroxyacetophenone was converted to target molecules GER-I and GER-B in 5 steps via sequential protection, aldol condensation, Michael type-cyclization, regioselective C-benzylation. The cellular growth inhibition of compounds GER-I and GER-II were investigated against P388, L1210, K562, HCT-15, SK-HepG-1, MCF-7 as cancer cell lines and mouse splenocytes as a normal cell by MTT assay.
- 제목
- 새로운 항암성 제리쿠드라닌 E 유도체의 합성 및 항암활성
- 제목 (타언어)
- Synthesis and Antitumour Activity of Novel Gericudranin E Derivatives
- 저자
- 박재호; 박경란; 호현순; 김희두; 표명윤
- 발행일
- 1999-10
- 저널명
- 약 학 회 지
- 권
- 43
- 호
- 5
- 페이지
- 559 ~ 565