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초록
Understanding of amyloid aggregation in terms of thermodynamics and kinetics is still limited. We herein examined the mechanism of 2-microglobulin amyloidogenesis using our unique method of isothermal titration calorimetry-based thermodynamic/kinetic measurements, and revealed the energy landscape of polymorphic amyloidogenesis under biological environment-mimicking conditions including shear forces and crowding effects.
키워드
ISOTHERMAL TITRATION CALORIMETRY; BETA(2)-MICROGLOBULIN; PROTEINS; HEAT
- 제목
- Energy landscape of polymorphic amyloid generation of 2-microglobulin revealed by calorimetry
- 저자
- Kinoshita, Misaki; Lin, Yuxi; Dai, Itoh; Okumura, Masaki; Markova, Natalia; Ladbury, John E.; Sterpone, Fabio; Lee, Young-Ho
- 발행일
- 2018-07
- 유형
- Article
- 권
- 54
- 호
- 57
- 페이지
- 7995 ~ 7998