Regiodivergent Addition of Allylic Acetals in Ruthenium-Catalyzed C-H/N-H Annulation Reaction

초록

Distinct reaction modes of pi-allylruthenium complexes, derived from allylic acetals, in the urazole-directed C-H/N-H annulation are described. By controlling the reaction conditions, electrophilic addition of pi-allylruthenium complexes at the alpha- and gamma-positions was selectively achieved, resulting in the formation of dihydrocinnolines and benzodiazepines, respectively. A series of control experiments for plausible reaction mechanism were performed.

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