Synthesis of diethylhexyl adipate by Candida antarctica lipase-catalyzed esterification
  • Kim, Heejin
  • Kim, Taehoon
  • Choi, Nakyung
  • Kim, Byung Hee
  • Oh, Se-Wook
  • 외 1명
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초록

Diethylhexyl adipate (DEHA) has been used for various applications in the chemical industry. In particular, DEHA is used as a plasticizer for polyvinyl chloride and its polymers. In this study, DEHA was successfully synthesized via lipase-catalyzed esterification from adipic acid with ethylhexanol in a solvent-free system. An immobilized lipase from Candida antarctica (Novozym 435) was used as a biocatalyst in this reaction. The optimal reaction conditions for the synthesis of DEHA were temperature of 50 degrees C, an enzyme loading of 5% (based on the total weight of substrate), a vacuum of 6.7 kPa, and a molar ratio 1:2.5 (adipic acid to ethylhexanol). When vacuum was applied, the conversion to DEHA was improved significantly and 100 mol% conversion was obtained within only 3 h under optimal condition.

키워드

Adipic acidDiethylhexyl adipateEsterificationPlasticizerNovozym 435ENZYMATIC-SYNTHESISETHYL-ESTER
제목
Synthesis of diethylhexyl adipate by Candida antarctica lipase-catalyzed esterification
저자
Kim, HeejinKim, TaehoonChoi, NakyungKim, Byung HeeOh, Se-WookKim, In-Hwan
DOI
10.1016/j.procbio.2018.12.030
발행일
2019-03
유형
Article
저널명
Process Biochemistry
78
페이지
58 ~ 62