상세 보기
- Lee, Sang-Jin;
- Leem, Young-Eun;
- Go, Ga-Yeon;
- Choi, Younhee;
- Song, Yoo Jin;
- ... Kim, Yong Kee;
- ... Bae, Gyu-Un;
- 외 4명
WEB OF SCIENCE
30SCOPUS
30초록
Prevention of age-associated reduction in muscle mass and function is required to manage a healthy life. Supplemental (-)-Epicatechin (EC) appears to act as a potential regulator for muscle growth and strength. However, its cellular and molecular mechanisms as a potential muscle growth agent have not been studied well. In the current study, we investigated a role of EC in differentiation of muscle progenitors to gain the molecular insight into how EC regulates muscle growth. EC enhanced myogenic differentiation in a dose-dependent manner through stimulation of promyogenic signaling pathways, p38MAPK and Akt. EC treatment elevated MyoD activity by enhancing its heterodimerization with E protein. Consistently, EC also positively regulated myogenic conversion and differentiation of fibroblasts. In conclusion, EC has a potential as a therapeutic or nutraceutical remedy to treat degenerative muscle diseases or age-related muscle weakness.
키워드
- 제목
- Epicatechin elicits MyoD-dependent myoblast differentiation and myogenic conversion of fibroblasts
- 저자
- Lee, Sang-Jin; Leem, Young-Eun; Go, Ga-Yeon; Choi, Younhee; Song, Yoo Jin; Kim, Insol; Kim, Do Yoon; Kim, Yong Kee; Seo, Dong-Wan; Kang, Jong-Sun; Bae, Gyu-Un
- 발행일
- 2017-04
- 유형
- Article
- 저널명
- PLoS ONE
- 권
- 12
- 호
- 4