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초록
Salubrinal is a specific eIF2 alpha phosphatase inhibitor that inhibits ER stress-mediated apoptosis. However, maintaining hyper-phosphorylated eIF2 alpha state with high doses of salubrinal treatment promotes apoptosis in some cancer cells. In this report, we found that salubrinal induced apoptosis of EBV-transformed B cells. Notably, salubrinal induced ROS generation and p38 MPAK activation, which then induced expression of FasL. Moreover, salubrinal subsequently led to activation of caspases, calcium redistribution, Bax translocation, cytochrome c release, and apoptosis. These findings suggest that salubrinal may be a novel therapeutic approach for EBV-associated malignant diseases. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
키워드
EBV; B cell; Salubrinal; ROS; p38 MAPK; Bax; Calcium; Apoptosis; ENDOPLASMIC-RETICULUM STRESS; CYTOCHROME-C RELEASE; PERMEABILITY TRANSITION; BCL-2 FAMILY; KINASE; MITOCHONDRIA; ACTIVATION; PHOSPHORYLATION; INHIBITION; PROTEINS
- 제목
- Reactive oxygen species and p38 MAPK regulate Bax translocation and calcium redistribution in salubrinal-induced apoptosis of EBV-transformed B cells
- 저자
- Park, Ga Bin; Kim, Yeong Seok; Lee, Hyun-Kyung; Song, Hyunkeun; Kim, Seonghan; Cho, Dae-Ho; Hur, Dae Young
- 발행일
- 2011-12
- 유형
- Article
- 저널명
- Cancer Letters
- 권
- 313
- 호
- 2
- 페이지
- 235 ~ 248