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Identification and Semi-Synthesis of 3-O-Protocatechuoylceanothic Acid, a Novel and Natural GPR120 Agonist
- Lim, Changjin;
- Park, Jung Gyu;
- Kang, Kyo Bin;
- Suh, Young-Ger
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1초록
The identification and three step synthesis of 3-O-protocatechuoylceanothic acid, a novel and natural GPR120 agonist, is described. This ceanothane-type triterpenoid was identified from the components of Ziziphus jujuba roots and was found to be a new GPR120 agonist with a novel structure. We synthetically converted ceanothic acid, which does not have GPR120 agonist activity, into 3-O-protocatechuoylceanothic acid in three steps. In addition, we present the corrected NMR spectrum of 3-O-protocatechuoylceanothic acid based on our synthesis.
키워드
G protein-coupled receptor; GPR120; agonist; 3-O-protocatechuoylceanothic acid; semi-synthesis; RECEPTOR; POTENT; PHARMACOLOGY; FFA4/GPR120; SECRETION; MOUSE
- 제목
- Identification and Semi-Synthesis of 3-O-Protocatechuoylceanothic Acid, a Novel and Natural GPR120 Agonist
- 저자
- Lim, Changjin; Park, Jung Gyu; Kang, Kyo Bin; Suh, Young-Ger
- 발행일
- 2019-10
- 유형
- Article
- 저널명
- Molecules
- 권
- 24
- 호
- 19