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L-형 칼슘 이온통로에 의한 파골세포 분화의 조절
The Regulation of Osteoclastogenesis by L-Type Channel Agonist
- 노아롱새미;
- 임미정
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We investigated the role of L-type Ca2+ channel in receptor activator of nuclear factor-kappaB ligand (RANKL)-induced osteoclast formation. BayK 8644, a L-type Ca2+ channel agonist, was shown to increase the RANKLinduced osteoclastogenesis and actin ring formation in mouse bone marrow-dereived macrophage (BMM) culture system. BayK 8644 stimulated RANKL-induced extracellular signal-regulated kinase (ERK) and p38 MAP kinase (MAPK) activation, which leads to increased nuclear factor of activated T cells (NFAT)c1 expression. Taken together, these data indicate that L-type Ca2+ channel regulates osteoclast formation possibly through ERK- and p38-mediated NFATc1 expression.
키워드
L-type Ca2+ channel; osteoclast; NFATc1; ERK; p38
- 제목
- L-형 칼슘 이온통로에 의한 파골세포 분화의 조절
- 제목 (타언어)
- The Regulation of Osteoclastogenesis by L-Type Channel Agonist
- 저자
- 노아롱새미; 임미정
- 발행일
- 2010-12
- 저널명
- 약 학 회 지
- 권
- 54
- 호
- 6
- 페이지
- 461 ~ 465