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초록
The endogenous H2S-driven theranostic H2S-Gem has been invented. The theranostic prodrug H2S-Gem is selectively activated in cancer cells, releasing active gemcitabine with a simultaneous fluorescence turn-on. H2S-Gem selectively inhibited cancer cell growth compared to the mother chemotherapeutic gemcitabine. Overall, it is a unique protocol for tracking and transporting chemotherapeutic agents to tumor areas without the guidance of tumor-directive ligands.
키워드
DRUG-DELIVERY; HYDROGEN-SULFIDE; THERANOSTIC PRODRUG; CANCER-THERAPY; PROBE
- 제목
- Cell-specific activation of gemcitabine by endogenous H2S stimulation and tracking through simultaneous fluorescence turn-on
- 저자
- Maiti, Mrinmoy; Yoon, Shin A; Cha, Yujin; Athul, K. K.; Bhuniya, Sankarprasad; Lee, Min Hee
- 발행일
- 2021-09
- 유형
- Article
- 권
- 57
- 호
- 75
- 페이지
- 9614 ~ 9617