Atomistic Modulations of Metal-Organic Frameworks for Printable Non-enzymatic Glucose Sensor on Plastic

초록

Metal-organic framework (MOF)-based nanomaterials have attracted significant attention as active elements in electrochemical sensors. Although some progress has been made in the preparation of pure MOF electrodes, their low sensitivities render electrochemical glucose sensing difficult. Accordingly, in this study, a novel concept of incorporating a benzoic acid (BA)-based supporting linker into a Ni-based MOF (Ni-MOF) was proposed to achieve highly sensitive non-enzymatic glucose sensors. Addition of the BA-based supporting linker enhanced the ratio of the high oxidation state of Ni, thereby increasing the number of active sites for glucose detection. Introduction of 10 wt% BA linker into Ni-MOF resulted in Ni-MOF-10 with excellent sensitivity and selectivity over a wide glucose concentration range of 0.5-2 mM, with a linear correlation coefficient of 0.9997. Furthermore, Ni-MOF-based three-electrode configurations were screen-printed on plastic substrates to fabricate flexible and non-enzymatic glucose sensors. The handcrafted device demonstrated potential as an electrochemical sensor for glucose detection. Thus, the proposed Ni-MOF is a viable candidate for the construction of wearable glucose sensors on plastic.

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