상세 보기
초록
A sesquiterpene was purified from Artemisia iwayomogi methanolic extract during the course of searching anti-inflammatory principle from medicinal plants. A sesquiterpene identified as armefolin inhibited the production of nitric oxide (NO) and attenuated inducible nitric oxide synthase (iNOS) protein level in lipopoly-saccharide (LPS)-activated RAW 264.7 cells. Armefolin also down-regulated mRNA expressions of iNOS and pro-inflammatory cytokines, interleukin-1β and interleukin-6 in LPS-activated macrophages. Moreover, armefolin suppressed the degradation of inhibitory-κBα (I-κBα) in LPS-activated macrophages. These data suggest that armefolin from A. iwayomogi can suppress the LPS-induced production of NO and the expression of iNOS gene through inhibiting the degradation of I-κBα. Taken together, armefolin from A. iwayomogi might be a candidate as promising anti-inflammatory agent. © 2017, Korean Society of Pharmacognosy. All rights reserved.
키워드
- 제목
- Inhibitory effect of a sesquiterpene from artemisia iwayomogi on expression of inducible nitric oxide synthase by suppression of I-κBα degradation in LPS-stimulated RAW 264.7 cells
- 저자
- Kim, Na Yeon; Koh, Hye Jin; Li, Hua; Lee, Hwa Jin; Ryu, Jae-Ha
- 발행일
- 2017-06
- 유형
- Article
- 권
- 23
- 호
- 2
- 페이지
- 92 ~ 96