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초록
Cyanidin-3-glucoside (C3G), an anthocyanin, is one of the most widespread dietary flavonoids. We investigatedthe effects of C3G in PMA/ionomycin (PI)-induced RBL-2H3 cells. C3G inhibited the production of IL-4 and IL-13 and alsodecreased the level of mRNA in a dose-dependent manner. Furthermore, western blot analysis implied that C3G down-regulatedthe protein level of c-Jun, NF-ATc1 and NF-κB but not c-Fos. Taken together, we suggest that C3G may have suppressiveeffects on Th2 cytokines and will be studied further to develop as functional foods that help alleviate allergysymptoms.
키워드
cyanidin-3-glucoside; IL-4; IL-13; RBL-2H3 cells; antiallergy
- 제목
- RBL-2H3 세포에서 Cyanidin-3-glucoside의 Th2 사이토카인 발현 억제 효과
- 제목 (타언어)
- Suppressive Effects of Cyanidin-3-glucoside on Th2 Cytokines Production in RBL-2H3 Cells
- 저자
- 정화현; 윤수정; 표명윤
- 발행일
- 2013-10
- 저널명
- 약 학 회 지
- 권
- 57
- 호
- 5
- 페이지
- 309 ~ 315