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Theragnosis by a miR-141-3p molecular beacon: simultaneous detection and sensitization of 5-fluorouracil resistant colorectal cancer cells through the activation of the TRIM13-associated apoptotic pathway
- Moon, Sung Ung;
- Park, Yongkeun;
- Park, Min Geun;
- Song, Sung Kyu;
- Jeong, Seok Hoo;
- 외 4명
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8초록
We developed a molecular beacon targeting miR-141-3p, aberrantly increased in 5-fluorouracil-resistant colorectal cancer cells (R-CRCCs). It consists of a fluorophore-labeled oligonucleotide, antisense to miR-141-3p, and a quencher. It detected R-CRCCs and recovered the chemosensitivity of them to 5-fluorouracil by hybridization with miR-141-3p, which is applicable to cancer treatment.
키워드
CHEMORESISTANCE
- 제목
- Theragnosis by a miR-141-3p molecular beacon: simultaneous detection and sensitization of 5-fluorouracil resistant colorectal cancer cells through the activation of the TRIM13-associated apoptotic pathway
- 저자
- Moon, Sung Ung; Park, Yongkeun; Park, Min Geun; Song, Sung Kyu; Jeong, Seok Hoo; Lee, Yong Seung; Heo, Hye Jung; Jung, Woon Yong; Kim, Soonhag
- 발행일
- 2019-07
- 유형
- Article
- 권
- 55
- 호
- 52
- 페이지
- 7466 ~ 7469