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Thymosin beta 4 enhances NK cell cytotoxicity mediated by ICAM-1
- Lee, Ha-reum;
- Yoon, Sun Young;
- Kang, Ho-Bum;
- Park, Sunyoung;
- Kim, Kyung-Eun;
- 외 8명
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19초록
Thymosin beta 4 (T beta 4), which is the major G-actin sequestering protein, has been shown to have ubiquitous distribution and multiple biological activities. However, T beta 4's functions in relation to natural killer (NK) cells are still unknown. In this study, we show that synthetic T beta 4 peptide increases NK cell cytotoxicity mediated by intercellular adhesion molecule-1 (ICAM-1) through the secretion of cytolytic granules to target cells. This suggests that T beta 4 is a key activator of NK cell cytotoxicity. (C) 2009 Elsevier B.V. All rights reserved.
키워드
Thymosin beta 4; NK cell cytotoxicity; ICAM-1; NATURAL-KILLER-CELLS; ADHESION MOLECULES; ENDOTHELIAL-CELLS; T-CELLS; ACTIVATION; IDENTIFICATION; PARTICIPATION; IMMUNOTHERAPY; LYMPHOCYTES; RECEPTORS
- 제목
- Thymosin beta 4 enhances NK cell cytotoxicity mediated by ICAM-1
- 저자
- Lee, Ha-reum; Yoon, Sun Young; Kang, Ho-Bum; Park, Sunyoung; Kim, Kyung-Eun; Cho, Young Hoon; Kim, Seonghan; Kim, Chul-woo; Cho, Byung Joo; Lee, Wang Jae; Bang, Sa Ik; Park, Hyunjeong; Cho, Daeho
- 발행일
- 2009-03
- 유형
- Article
- 권
- 123
- 호
- 1
- 페이지
- 72 ~ 76
- 언어
- ENG
- 출판사
- ELSEVIER
- 발행국가
- 네덜란드
- 분량
- 5 페이지
- ISSN
- E 1879-0542
P 0165-2478