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High-throughput identification of substrate specificity for protein kinase by using an improved one-bead-one-compound library approach
- Kim, Yun-Gon;
- Shin, Dong-Sik;
- Kim, Eun-Mi;
- Park, Hyung-Yeon;
- Lee, Chang-Soo;
- 외 4명
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23Citations
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27초록
(Graph Presented) Pick and choose: The identification of the substrate specificity of a protein kinase is critical in understanding its role and function in a cellular signal transduction network. A high-throughput platform was developed for the identification of tyrosine kinase substrate specificity by using an improved one-bead-one-compound ladder peptide library and MALDI-TOF MS.
키워드
enzymes; high-throughput screening; mass spectrometry; peptides; substrate specificity; TYROSINE KINASES; COMBINATORIAL LIBRARIES; MASS-SPECTROMETRY; DRUG DISCOVERY; C-SRC; RECEPTOR; ZAP-70; AFFINITY; CANCER; DOMAIN
- 제목
- High-throughput identification of substrate specificity for protein kinase by using an improved one-bead-one-compound library approach
- 저자
- Kim, Yun-Gon; Shin, Dong-Sik; Kim, Eun-Mi; Park, Hyung-Yeon; Lee, Chang-Soo; Kim, June-Hyung; Lee, Bon-Su; Lee, Yoon-Sik; Kim, Byung-Gee
- 발행일
- 2007-07
- 권
- 46
- 호
- 28
- 페이지
- 5408 ~ 5411
- 언어
- ENG
- 출판사
- John Wiley & Sons Ltd.
- 발행국가
- 독일
- 분량
- 4 페이지
- ISSN
- E 1521-3773
P 1433-7851