상세 보기
- Yoo, Young A.;
- Na, Ah Ram;
- Lee, Myeong-Sok;
- Yoon, Sukjoon;
- Kim, Jun Suk;
- 외 1명
WEB OF SCIENCE
10SCOPUS
11초록
The constitutive activation of JNK has been implicated in Ras-induced cellular transformation and activated JNK is down-regulated by the tumor suppressor protein, RASSF1A. In this study, we examined whether RASSF1A blocked oncogenic Ras-induced JNK activation. Exogenous expression of H-RaSG12V induced JNK phosphorylation and RASSF1A co-transfected with H-RaSG12V efficiently suppressed Ras-triggered JNK activation in various cancer cell lines. RASSF1A expression revived the H-Ras(G12V)-induced P27(Kip1) down-regulation. JNK siRNA treatment also promoted recovery from the H-Ras(G12V)-induced p27(Kip1) down-regulation. These results demonstrate that RASSF1A inhibited H-Ras(G12V)-induced JNK activation and JNK-mediated p27(Kip1) down-regulation. From these results, we propose that RASSFIA exerts a tumor-suppressing effect by blocking oncogenic Ras-induced JNK activation.
키워드
- 제목
- RASSF1A suppresses oncogenic H-Ras-induced c-Jun N-terminal kinase activation
- 저자
- Yoo, Young A.; Na, Ah Ram; Lee, Myeong-Sok; Yoon, Sukjoon; Kim, Jun Suk; Yoo, Young Do
- 발행일
- 2006-12
- 유형
- Article
- 권
- 29
- 호
- 6
- 페이지
- 1541 ~ 1547