상세 보기
- Jung, Samil;
- Li, Chengping;
- Jeong, Dongjun;
- Lee, Soonduck;
- Ohk, Jiyeon;
- ... Yang, Young;
- ... Kim, Keun-Il;
- 외 7명
WEB OF SCIENCE
58SCOPUS
57초록
A 34-KD protein encoded by the SEI-1 gene (p34(SEI-1)), is a relatively recently discovered oncoprotein that has multiple important biological functions. Our data show that p34(SEI-1) enhances cancer cell survival and promotes tumorigenesis by downregulating the tumor suppressor PTEN, a negative regulator of the PI3K/AKT signaling pathway, and therefore activating the PI3K/AKT signaling pathway. In this process, p34(SEI-1) positively affects NEDD4-1 gene expression both at the transcriptional and protein levels. Furthermore, the expression levels of p34(SEI-1) and NEDD4-1 were found to be coordinated in tumor tissues obtained from patients with breast cancer. We also show that p34(SEI-1) affects the subcellular localization of PTEN.
키워드
- 제목
- Oncogenic function of p34(SEI-1) via NEDD4-1-mediated PTEN ubiquitination/degradation and activation of the PI3K/AKT pathway
- 저자
- Jung, Samil; Li, Chengping; Jeong, Dongjun; Lee, Soonduck; Ohk, Jiyeon; Park, Meeyoung; Han, Songyi; Duan, Jingjing; Kim, Changjin; Yang, Young; Kim, Keun-Il; Lim, Jong-Seok; Kang, Young-Sook; Lee, Myeong-Sok
- 발행일
- 2013-11
- 유형
- Article
- 권
- 43
- 호
- 5
- 페이지
- 1587 ~ 1595