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초록
Polygonum cuspidatum which is widely distributed in Korea has been used as treatments of dermatitis, gonorrhea,favus athlete's foot, hyperlipidemia and inflammation in traditional medicine. We examined anti-oxidant and antiinflammatoryactivity by measuring DPPH radical scavenging activity and the inhibition of IFN-γ and LPS-induced NO productionin RAW 264.7 murine macrophage cells. We isolated and characterized resveratrol (1), trans-resveratrol 3-O-β-Dglucopyranoside(2). Compounds 1 and 2 showed potent activities compared with L-NMMA (NG-monomethyl-L-arginine). These results suggested that the stilbene compounds isolated from Polygonum cuspidatum might be used as antiinflammatoryagents.
키워드
Polygonum cuspidatum; resveratrol; trans-resveratrol 3-O-β-D-glucopyranoside; antiinflammatory agents
- 제목
- 호장으로부터 분리한 스틸벤류의 Nitric Oxide 저해활성
- 제목 (타언어)
- Inhibition of Nitric Oxide Production by Stilbenes from Polygonum cuspidatum
- 저자
- 주시몽; 홍윤정; 양기숙
- 발행일
- 2014-02
- 저널명
- 약 학 회 지
- 권
- 58
- 호
- 1
- 페이지
- 12 ~ 15