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초록
To determine whether or not bisphenol A affects the immune system, female ICR mice were treatedbisphenol A(BPA) orally at the doses of 100, 500 and 1,000mg/kg for 30 consecutive days. Four days beforeenumerating plaque-forming cells (PFCs) mice were immunized intraperitoneally with sheep red blood cells(SRBCs). The spleen cellularity and PFC/spleen were significantly reduced by 30--2, the lymphocyteproliferation ex vivo was not significantly suppressed by BPA. Our present results indicated that 30-dayexposure of mice to BPA might have mild immunotoxic potential.
키워드
Bisphenol A; IgM- PFC; splenic proliferation; Bisphenol A; IgM- PFC; splenic proliferation
- 제목
- 마우스에서 Bisphenol A의 아급성노출이 IgM-PFC형성능과 비장세포 증식능에 미치는 영향
- 제목 (타언어)
- Effects of Subacute Oral Administration of Bisphenol A on the IgM-PFC and Proliferation of Splenocytes in Mice
- 저자
- 변정아; 표명윤
- 발행일
- 2003-09
- 저널명
- 환경독성보건학회지
- 권
- 18
- 호
- 3
- 페이지
- 231 ~ 235