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초록
Two new sesquiterpenoids, siegenolides A (1) and B (2), and two known sesquiterpenes 3 and 4 were isolated from Siegesbeckia glabrescens. Their structures were elucidated by spectroscopic analyses, and they were further evaluated for their cytotoxic activities against human cancer cells (MCF-7, AsPC-1, SW480, HCT 116, HepG2, HeLa). Compounds 1-4 showed differential cytotoxic effects on the target cancer cells with IC50 values in the range of 0.9-33.3 mu M.
키워드
Compositae; Cytotoxicity; Sesquiterpenoids; Siegesbeckia glabrescens; IN-VITRO
- 제목
- New Cytotoxic Sesquiterpenoids from Siegesbeckia glabrescens
- 저자
- Wu, Qian; Li, Hua; Lee, So Yoon; Lee, Hwa Jin; Ryu, Jae-Ha
- 발행일
- 2015-02
- 유형
- Article
- 저널명
- Molecules
- 권
- 20
- 호
- 2
- 페이지
- 2850 ~ 2856