상세 보기
- Lee, Jong Hyuk;
- Chung, Yoon Hee;
- Kim, Ho Hyun;
- Bang, Joon Seok;
- Jung, Tae Woo;
- 외 5명
WEB OF SCIENCE
12SCOPUS
14초록
The aim of the present study was to examine the effects of p-coumaric acid on the longitudinal growth of the long bone in adolescent male rats. Teatment with p-coumaric acid significantly increased the tibial length and the height of each growth plate zone and the ratio of 5-bromo-2'-deoxyuridine-positive cells relative to total proliferative cells. Expression of insulin-like growth factor 1 and its receptor in the proliferative and hypertrophic zones, and serum levels of growth hormone and insulin-like growth factor 1 were significantly increased as well in the p-coumaric acid-treated group. Via increasing both the serum level of insulin-like growth factor 1 and its expression, p-coumaric acid could promote cell proliferation in growth plate zones. These results suggest that p-coumaric acid has the potential to increase height and may be a feasible alternative to growth hormone therapy. (C) 2018 Elsevier Inc. All rights reserved.
키워드
- 제목
- p-Coumaric acid stimulates longitudinal bone growth through increasing the serum production and expression levels of insulin-like growth factor 1 in rats
- 저자
- Lee, Jong Hyuk; Chung, Yoon Hee; Kim, Ho Hyun; Bang, Joon Seok; Jung, Tae Woo; Park, Taekwang; Park, Jinwoo; Kim, Uiseok; Lee, Sung Hoon; Jeong, Ji Hoon
- 발행일
- 2018-11
- 유형
- Article
- 권
- 505
- 호
- 4
- 페이지
- 1103 ~ 1106